| JOHNSON & JOHNSON (JNJ) | $94.19B | 28.5% | 30.9× | $653.54B |
| ELI LILLY & Co (LLY) | $65.18B | 31.7% | 38.9× | $1.03T |
| Merck & Co., Inc. (MRK) | $65.01B | 28.1% | 118.0× | $369.73B |
| PFIZER INC (PFE) | $62.58B | 12.4% | 37.6× | $162.73B |
| AbbVie Inc. (ABBV) | $61.16B | 6.9% | 72.4× | $459.43B |
| BRISTOL MYERS SQUIBB CO (BMY) | $48.19B | 14.6% | 14.7× | $136.70B |
| ABBOTT LABORATORIES (ABT) | $44.33B | 14.7% | 35.3× | $188.49B |
| TEVA PHARMACEUTICAL INDUSTRIES LTD (TEVA) | $17.26B | 8.2% | 60.3× | $42.17B |
| REGENERON PHARMACEUTICALS, INC. (REGN) | $14.34B | 31.4% | 19.8× | $84.82B |
| Viatris Inc (VTRS) | $14.25B | -24.7% | — | $19.40B |
| VERTEX PHARMACEUTICALS INC / MA (VRTX) | $12.00B | 32.9% | 31.7× | $138.81B |
| Bausch Health Companies Inc. (BHC) | $10.27B | 1.5% | 15.2× | $2.38B |
| Zoetis Inc. (ZTS) | $9.47B | 28.2% | 12.6× | $31.92B |
| Organon & Co. (OGN) | $6.22B | 3.0% | 17.7× | $3.62B |
| BeOne Medicines Ltd. (ONC) | $5.34B | 5.4% | 64.4× | $40.57B |
| Elanco Animal Health Inc (ELAN) | $4.71B | -4.9% | — | $12.53B |
| Jazz Pharmaceuticals plc (JAZZ) | $4.27B | -8.3% | — | $16.18B |
| PERRIGO Co plc (PRGO) | $4.25B | -33.5% | — | $1.99B |
| ALNYLAM PHARMACEUTICALS, INC. (ALNY) | $3.71B | 8.4% | 43.0× | $32.93B |
| BIOMARIN PHARMACEUTICAL INC (BMRN) | $3.22B | 10.8% | 177.3× | $12.70B |
| UNITED THERAPEUTICS Corp (UTHR) | $3.18B | 41.9% | 18.3× | $21.99B |
| Amneal Pharmaceuticals, Inc. (AMRX) | $3.02B | 2.4% | 36.5× | $6.11B |
| Royalty Pharma plc (RPRX) | $2.38B | 32.4% | 33.5× | $36.01B |
| Sarepta Therapeutics, Inc. (SRPT) | $2.20B | -32.5% | — | $2.20B |
| PTC THERAPEUTICS, INC. (PTCT) | $1.73B | 39.4% | 9.0× | $5.85B |
| PHIBRO ANIMAL HEALTH CORP (PAHC) | $1.52B | 6.6% | 15.5× | $1.56B |
| Alkermes plc. (ALKS) | $1.48B | 16.4% | 124.8× | $7.95B |
| Indivior Pharmaceuticals, Inc. (INDV) | $1.24B | 16.9% | 12.5× | $4.12B |
| Nasus Pharma Ltd (NSRX) | $1.24B | -0.5% | — | $48.0M |
| Prestige Consumer Healthcare Inc. (PBH) | $1.09B | 17.5% | 14.7× | $2.49B |
| ACADIA PHARMACEUTICALS INC (ACAD) | $1.07B | 36.5% | 13.1× | $5.02B |
| MADRIGAL PHARMACEUTICALS, INC. (MDGL) | $958.4M | -30.1% | — | $12.33B |
| IONIS PHARMACEUTICALS INC (IONS) | $943.7M | -40.4% | — | $10.15B |
| ANI PHARMACEUTICALS INC (ANIP) | $883.4M | 8.9% | 16.0× | $1.68B |
| Harmony Biosciences Holdings, Inc. (HRMY) | $868.5M | 18.3% | 12.7× | $2.28B |
| ARROWHEAD PHARMACEUTICALS, INC. (ARWR) | $829.4M | -0.2% | — | $12.51B |
| COLLEGIUM PHARMACEUTICAL, INC (COLL) | $780.6M | 8.1% | 20.0× | $785.8M |
| CORCEPT THERAPEUTICS INC (CORT) | $761.4M | 13.1% | 258.8× | $12.31B |
| Emergent BioSolutions Inc. (EBS) | $742.9M | 7.1% | 6.4× | $303.0M |
| Pacira BioSciences, Inc. (PCRX) | $726.4M | 1.0% | 73.6× | $1.03B |
| Amphastar Pharmaceuticals, Inc. (AMPH) | $719.9M | 13.6% | 13.3× | $976.7M |
| SUPERNUS PHARMACEUTICALS, INC. (SUPN) | $719.0M | -5.4% | — | $2.54B |
| Kiniksa Pharmaceuticals International, plc (KNSA) | $677.6M | 8.7% | 80.1× | $6.19B |
| Ultragenyx Pharmaceutical Inc. (RARE) | $673.0M | -85.4% | — | $2.52B |
| Axsome Therapeutics, Inc. (AXSM) | $638.5M | -28.7% | — | $10.42B |
| TG THERAPEUTICS, INC. (TGTX) | $616.3M | 72.6% | 19.7× | $8.26B |
| OPKO HEALTH, INC. (OPK) | $606.9M | -37.2% | — | $1.10B |
| INSMED Inc (INSM) | $606.4M | — | — | $26.54B |
| CATALYST PHARMACEUTICALS, INC. (CPRX) | $589.0M | 36.4% | 18.2× | $3.85B |
| Organogenesis Holdings Inc. (ORGO) | $564.2M | 6.6% | 11.5× | $221.3M |
| HUTCHMED (China) Ltd (HCM) | $548.5M | 83.3% | 123.8× | $2.15B |
| Mirum Pharmaceuticals, Inc. (MIRM) | $521.3M | -4.5% | — | $5.98B |
| BridgeBio Pharma, Inc. (BBIO) | $502.1M | — | — | $14.97B |
| Travere Therapeutics, Inc. (TVTX) | $490.7M | -5.2% | — | $6.25B |
| NATURES SUNSHINE PRODUCTS INC (NATR) | $480.1M | 4.1% | 14.2× | $249.0M |
| Zai Lab Ltd (ZLAB) | $457.2M | -38.4% | — | $2.84B |
| Innoviva, Inc. (INVA) | $411.3M | 65.9% | 4.8× | $1.50B |
| ARDELYX, INC. (ARDX) | $407.3M | -15.1% | — | $970.8M |
| Esperion Therapeutics, Inc. (ESPR) | $403.1M | -5.6% | — | $819.5M |
| SINOVAC BIOTECH LTD (SVA) | $386.0M | -51.5% | — | — |
| Arcutis Biotherapeutics, Inc. (ARQT) | $372.1M | -4.3% | — | $2.99B |
| MANNKIND CORP (MNKD) | $349.0M | 1.7% | 200.5× | $1.29B |
| CorMedix Inc. (CRMD) | $311.7M | 52.3% | 3.8× | $643.8M |
| Evolus, Inc. (EOLS) | $297.2M | -17.4% | — | $600.4M |
| IRONWOOD PHARMACEUTICALS INC (IRWD) | $296.2M | 8.1% | 5.4× | $702.3M |
| RIGEL PHARMACEUTICALS INC (RIGL) | $294.3M | — | 2.7× | $862.6M |
| Xeris Biopharma Holdings, Inc. (XERS) | $291.8M | 0.2% | — | $1.54B |
| Aurinia Pharmaceuticals Inc. (AUPH) | $283.1M | — | 7.1× | $2.17B |
| HARROW, INC. (HROW) | $272.3M | -1.9% | — | $1.38B |
| Vireo Growth Inc. (VREOF) | $268.8M | -25.3% | — | $557.1M |
| LIGAND PHARMACEUTICALS INC (LGND) | $268.1M | 46.4% | 29.0× | $5.74B |
| ARVINAS, INC. (ARVN) | $262.6M | -30.8% | — | $592.3M |
| Schrodinger, Inc. (SDGR) | $255.9M | -40.4% | — | $1.56B |
| Arcus Biosciences, Inc. (RCUS) | $247.0M | — | — | $3.87B |
| Keros Therapeutics, Inc. (KROS) | $243.9M | 35.7% | 4.8× | $220.5M |
| Akebia Therapeutics, Inc. (AKBA) | $236.2M | -2.3% | — | $254.6M |
| ANAPTYSBIO, INC (ANAB) | $234.6M | -5.6% | — | $1.67B |
| PUMA BIOTECHNOLOGY, INC. (PBYI) | $228.4M | 13.6% | 18.3× | $472.8M |
| IDEAYA Biosciences, Inc. (IDYA) | $218.7M | -52.0% | — | $4.03B |
| Vanda Pharmaceuticals Inc. (VNDA) | $216.1M | — | — | $319.8M |
| AMARIN CORP PLC\UK (AMRN) | $213.6M | -18.2% | — | $295.1M |
| RHYTHM PHARMACEUTICALS, INC. (RYTM) | $189.8M | — | — | $7.38B |
| MARAVAI LIFESCIENCES HOLDINGS, INC. (MRVI) | $185.7M | -70.4% | — | $2.70B |
| Stoke Therapeutics, Inc. (STOK) | $184.4M | -3.7% | — | $2.04B |
| Lifevantage Corp (LFVN) | $182.6M | 2.8% | 14.3× | $81.4M |
| Cryoport, Inc. (CYRX) | $176.2M | 44.4% | 11.8× | $839.3M |
| Phathom Pharmaceuticals, Inc. (PHAT) | $175.1M | — | — | $723.3M |
| Syndax Pharmaceuticals Inc (SNDX) | $172.4M | — | — | $1.74B |
| Liquidia Corp (LQDA) | $158.3M | -43.5% | — | $6.26B |
| HERON THERAPEUTICS, INC. /DE/ (HRTX) | $154.9M | -13.0% | — | $63.0M |
| MACROGENICS INC (MGNX) | $149.5M | -49.9% | — | $259.9M |
| ELITE PHARMACEUTICALS INC /NV/ (ELTP) | $148.9M | 30.1% | 5.8× | $312.4M |
| Karyopharm Therapeutics Inc. (KPTI) | $146.1M | — | — | $44.0M |
| LIFECORE BIOMEDICAL, INC. \DE\ (LFCR) | $128.9M | -30.0% | — | $171.9M |
| Xencor Inc (XNCR) | $125.6M | -73.2% | — | $1.94B |
| GYRE THERAPEUTICS, INC. (GYRE) | $116.6M | 8.5% | 334.0× | $708.3M |
| UroGen Pharma Ltd. (URGN) | $109.8M | — | — | $2.13B |
| Theravance Biopharma, Inc. (TBPH) | $107.5M | 98.5% | 16.4× | $885.2M |
| ZEVRA THERAPEUTICS, INC. (ZVRA) | $106.5M | 78.2% | 12.4× | $686.8M |
| Zymeworks Inc. (ZYME) | $106.0M | -76.6% | — | $2.02B |
| SIGA TECHNOLOGIES INC (SIGA) | $94.6M | 24.6% | 9.6× | $219.9M |
| CYTOKINETICS INC (CYTK) | $88.0M | — | — | $11.01B |
| LakeShore Biopharma Co., Ltd. (LSBCF) | $85.7M | -16.3% | — | — |
| STANDARD BIOTOOLS INC. (LAB) | $85.3M | -87.8% | — | $256.4M |
| ARS Pharmaceuticals, Inc. (SPRY) | $84.3M | — | — | $585.7M |
| Nurix Therapeutics, Inc. (NRIX) | $84.0M | — | — | $2.79B |
| Arcturus Therapeutics Holdings Inc. (ARCT) | $82.0M | -80.2% | — | $419.5M |
| ADC Therapeutics SA (ADCT) | $81.4M | — | — | $158.3M |
| Eton Pharmaceuticals, Inc. (ETON) | $80.0M | -5.8% | — | $1.79B |
| CytomX Therapeutics, Inc. (CTMX) | $76.2M | -22.8% | — | $723.4M |
| AbCellera Biologics Inc. (ABCL) | $75.1M | — | — | $3.66B |
| BICYCLE THERAPEUTICS PLC (BCYC) | $72.6M | — | — | $304.8M |
| ASSEMBLY BIOSCIENCES, INC. (ASMB) | $72.3M | -8.5% | — | $716.3M |
| Viridian Therapeutics, Inc.\DE (VRDN) | $70.8M | — | — | $2.61B |
| ROCKWELL MEDICAL, INC. (RMTI) | $69.3M | -7.7% | — | $32.9M |
| Kura Oncology, Inc. (KURA) | $67.5M | — | — | $1.17B |
| Spero Therapeutics, Inc. (SPRO) | $66.8M | 12.8% | 8.6× | $69.9M |
| AYTU BIOPHARMA, INC (AYTU) | $66.4M | -20.4% | — | $24.7M |
| ENANTA PHARMACEUTICALS INC (ENTA) | $65.3M | — | — | $401.9M |
| Nuvation Bio Inc. (NUVB) | $62.9M | — | — | $2.34B |
| Tango Therapeutics, Inc. (TNGX) | $62.4M | — | — | $3.94B |
| Journey Medical Corp (DERM) | $61.2M | -18.7% | — | $213.7M |
| Fortress Biotech, Inc. (FBIO) | $61.2M | 11.1% | 1.0× | $89.4M |
| NEKTAR THERAPEUTICS (NKTR) | $55.2M | — | — | $2.55B |
| INTEGRATED BIOPHARMA INC (INBP) | $54.4M | 1.5% | 6.3× | $5.9M |
| AGIOS PHARMACEUTICALS, INC. (AGIO) | $54.0M | — | — | $1.99B |
| Q32 Bio Inc. (QTTB) | $53.7M | 55.5% | 4.8× | $447.4M |
| XOMA Royalty Corp (XOMA) | $52.1M | 60.8% | 25.6× | $710.2M |
| OCULAR THERAPEUTIX, INC (OCUL) | $52.0M | — | — | $2.38B |
| LEXICON PHARMACEUTICALS, INC. (LXRX) | $49.8M | — | — | $1.02B |
| Gossamer Bio, Inc. (GOSS) | $48.5M | — | — | $83.2M |
| Protagonist Therapeutics, Inc (PTGX) | $46.0M | — | — | $9.56B |
| Septerna, Inc. (SEPN) | $46.0M | — | — | $1.82B |
| Aquestive Therapeutics, Inc. (AQST) | $44.5M | — | — | $641.4M |
| CUMBERLAND PHARMACEUTICALS INC (CPIX) | $44.5M | -6.4% | — | $134.4M |
| Xilio Therapeutics, Inc. (XLO) | $43.8M | -80.1% | — | $59.2M |
| Wave Life Sciences, Inc. (WVE) | $42.7M | — | — | $993.1M |
| Biofrontera Inc. (BFRI) | $41.7M | -25.3% | — | $22.7M |
| BGM Group Ltd. (BGM) | $37.9M | -52.6% | — | $109.3M |
| LFTD PARTNERS INC. (LIFD) | $36.9M | -67.3% | — | $1.5M |
| Sunshine Biopharma Inc. (SBFM) | $36.3M | -16.5% | — | $4.5M |
| Earth Science Tech, Inc. (ETST) | $35.7M | 10.2% | 9.3× | $26.8M |
| Verrica Pharmaceuticals Inc. (VRCA) | $35.6M | -50.3% | — | $97.7M |
| BIOHARVEST SCIENCES INC. (BHST) | $34.5M | -32.3% | — | $45.3M |
| Zomedica Corp. (ZOMDF) | $32.0M | — | — | $80.4M |
| Verastem, Inc. (VSTM) | $30.9M | — | — | $653.9M |
| Foghorn Therapeutics Inc. (FHTX) | $30.9M | — | — | $369.4M |
| Cue Biopharma, Inc. (CUE) | $27.5M | -96.9% | — | $209.6M |
| Celularity Inc (CELU) | $26.6M | — | — | $25.5M |
| Entrada Therapeutics, Inc. (TRDA) | $25.4M | — | — | $272.6M |
| ALUMIS INC. (ALMS) | $24.1M | — | — | $2.82B |
| NewAmsterdam Pharma Co N.V. (NAMS) | $22.5M | — | — | $3.03B |
| CASI Pharmaceuticals, Inc. (CASIF) | $20.7M | — | — | $2.7M |
| SCYNEXIS INC (SCYX) | $20.6M | -41.8% | — | $53.6M |
| Evofem Biosciences, Inc. (EVFM) | $20.2M | 1.9% | — | $1.1M |
| Sol-Gel Technologies Ltd. (SLGL) | $19.4M | -31.6% | — | $225.3M |
| Universe Pharmaceuticals INC (UPC) | $17.9M | -20.6% | — | $3.3M |
| Zhengye Biotechnology Holding Ltd (ZYBT) | $16.6M | -60.0% | — | $82.0M |
| uniQure N.V. (QURE) | $16.1M | — | — | $3.38B |
| Neuphoria Therapeutics Inc. (NEUP) | $15.6M | -2.4% | — | $20.3M |
| Opus Genetics, Inc. (IRD) | $14.2M | — | — | $320.3M |
| Arbutus Biopharma Corp (ABUS) | $14.1M | — | — | $1.01B |
| Pyxis Oncology, Inc. (PYXS) | $13.9M | — | — | $269.4M |
| CV Sciences, Inc. (CVSI) | $13.8M | -6.9% | — | $4.5M |
| Tonix Pharmaceuticals Holding Corp. (TNXP) | $13.1M | — | — | $233.1M |
| Evommune, Inc. (EVMN) | $13.0M | — | — | $480.1M |
| Emmaus Life Sciences, Inc. (EMMA) | $12.5M | -60.2% | — | $3.6M |
| Prelude Therapeutics Inc (PRLD) | $12.1M | — | — | $436.5M |
| Jaguar Health, Inc. (JAGX) | $11.5M | — | — | $4.2M |
| CRESCENT BIOPHARMA, INC. (CBIO) | $10.8M | — | — | $659.7M |
| Janux Therapeutics, Inc. (JANX) | $10.0M | — | — | $1.10B |
| Zenas BioPharma, Inc. (ZBIO) | $10.0M | — | — | $2.04B |
| PROTHENA CORP PUBLIC LTD CO (PRTA) | $9.7M | — | — | $479.0M |
| Roivant Sciences Ltd. (ROIV) | $8.3M | — | — | $24.93B |
| Aclaris Therapeutics, Inc. (ACRS) | $7.8M | — | — | $884.7M |
| Adagene Inc. (ADAG) | $7.7M | — | — | $235.7M |
| Whitehawk Therapeutics, Inc. (WHWK) | $7.1M | — | — | $263.4M |
| Immunome Inc. (IMNM) | $6.9M | — | — | $3.13B |
| KYNTRA BIO, INC. (KYNB) | $6.4M | — | — | $32.5M |
| ProPhase Labs, Inc. (PRPH) | $4.3M | — | — | $311,851 |
| Cartesian Therapeutics, Inc. (RNAC) | $2.8M | — | — | $290.5M |
| Lipocine Inc. (LPCN) | $2.0M | — | — | $17.9M |
| Silence Therapeutics plc (SLN) | $559,000 | — | — | $834.1M |
| Mereo BioPharma Group plc (MREO) | $500,000 | — | — | $40.3M |
| Connect Biopharma Holdings Ltd (CNTB) | $64,000 | — | — | $146.7M |
| Amylyx Pharmaceuticals, Inc. (AMLX) | $0 | — | — | $3.77B |
| Barinthus Biotherapeutics plc. (BRNS) | $0 | — | — | $29.9M |
| CAPRICOR THERAPEUTICS, INC. (CAPR) | $0 | — | — | $544.2M |
| Fulcrum Therapeutics, Inc. (FULC) | $0 | — | — | $293.7M |
| KIORA PHARMACEUTICALS INC (KPRX) | $0 | — | — | $11.6M |
| Lite Strategy, Inc. (LITS) | $0 | — | — | $34.0M |
| SPRUCE BIOSCIENCES, INC. (SPRB) | $0 | — | — | $174.7M |
| Zentalis Pharmaceuticals, Inc. (ZNTL) | $0 | — | — | $359.8M |
| Contineum Therapeutics, Inc. (CTNM) | — | — | — | $622.6M |
| Equillium, Inc. (EQ) | — | — | — | $155.3M |
| PALVELLA THERAPEUTICS, INC. (PVLA) | — | — | — | $2.16B |
| Tvardi Therapeutics, Inc. (TVRD) | — | — | — | $24.3M |
| VERU INC. (VERU) | — | — | — | $44.8M |
