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Nasdaq · Healthcare

Harmony Biosciences Holdings, Inc. (HRMY)

As-reported financials and SEC filings for Harmony Biosciences Holdings, Inc. The latest annual period is FY2025. The latest reported quarter is Q2 FY2026. Financial statements come straight from the company’s EDGAR filings; valuation figures such as P/E and market cap use market data.

About Harmony Biosciences Holdings, Inc.

Harmony Biosciences Holdings, Inc. develops and commercializes treatments for rare neurological diseases, focusing on sleep/wake disorders, rare epilepsy, and neurobehavioral conditions. Its main product, WAKIX (pitolisant), is an FDA-approved oral therapy for narcolepsy that is not classified as a controlled substance. The company also advances clinical programs for pitolisant in conditions like idiopathic hypersomnia and Prader-Willi syndrome, and it develops therapies for rare epilepsies through acquired assets and collaborations.

Snapshot

Revenue
$868.5M
Revenue growth (YoY)
21.5%
Net income
$158.7M
Diluted EPS
$2.71
Gross margin
77.2%
Operating margin
24.0%
Net margin
18.3%
FCF margin
40.1%
ROE
18.2%
net income / fiscal-year-end equity
P/E
12.7×
trailing when available, otherwise FY EPS
Market cap
$2.28B
Long-term debt / equity
0.17×
non-current term debt only

Fundamentals are from SEC filings for FY2025, the latest annual period (ended December 31, 2025). P/E and market cap are derived from stored market prices, last retrieved on a rolling basis and typically within the past week.

What changed at Harmony Biosciences Holdings

  • Revenue grew 21.5% to $868M in FY2025, in line with the 22.8% the year before.
  • Operating margin is 24.0% in FY2025, -4.7 pp against 28.7% in FY2021.
  • Most recent quarter Q2 FY2026: revenue $261M, up 30.3% from Q2 FY2025.
  • Free cash flow was $348M in FY2025, 40.1% of revenue.
  • Net income rose 9.1% to $159M in FY2025.

Computed from the as-reported figures in the statements below. A change we cannot state from filed figures is left out rather than estimated.

Peer comparison

Where Harmony Biosciences Holdings’s fundamentals sit among the 198 pharmaceutical companies. Each figure is ranked only against peers that report it, from lowest (left) to highest (right).

Gross margin77.2%
72nd percentile of 69
Operating margin24.0%
87th percentile of 113
Net margin18.3%
80th percentile of 122
FCF margin40.1%
94th percentile of 110
Revenue growth (YoY)+21.5%
62nd percentile of 187
ROE18.2%
84th percentile of 167
P/E12.7×
34th percentile of 60
Long-term debt / equity0.17×
30th percentile of 64
Short interest4.77d
40th percentile of 197

Harmony Biosciences Holdings’s FCF margin of 40.1% ranks in the 94th percentile of the 110 pharmaceutical companies reporting it. Harmony Biosciences Holdings’s operating margin of 24.0% ranks in the 87th percentile of the 113 pharmaceutical companies reporting it.

No reported insider transactions (codes P/S) in the last 90 days. For context, about 15% of companies in the universe saw any reported insider purchase (code P) in the same window. Browse insider activity →

Percentiles describe where a figure sits among industry peers reporting it (100th = highest). They are position within a peer group, not a rating, and not investment advice. Short interest ranking uses days to cover from FINRA Consolidated Short Interest data; FINRA is the owner and source of that data, included at no additional charge.

Institutional ownership

Held by 2 of the superinvestors we track (plus 6 quant / multi-strat books), based on each investor’s most recent 13F; periods vary by investor (newest: Q2 2026).

Conviction investors
2
+6 quant / multi-strat
Initiated / added
3
0 new, 3 added
Reduced / exited
5
5 trimmed, 0 exited
Combined position
$145.7M
reported long value
InvestorAs ofPosition valueSharesChange
Renaissance TechnologiesquantQ2 2026$43.5M1.2MAdded
Two Sigma InvestmentsquantQ2 2026$34.9M959.1KAdded
AQR Capital ManagementquantQ2 2026$34.0M934.3KAdded
Millennium ManagementquantQ2 2026$11.6M319.8KReduced
Citadel AdvisorsquantQ2 2026$9.3M255.8KReduced
Bridgewater AssociatesQ2 2026$9.1M248.6KReduced
D. E. ShawquantQ2 2026$1.9M52.9KReduced
Gotham Asset ManagementQ2 2026$1.3M35.9KReduced

From quarterly Form 13F filings, which can be up to 45 days delayed. Long US-listed positions only: excludes short positions, options, cash, bonds, and non-US holdings, so this is not a manager’s complete portfolio. Counts are of the investors we track, not all institutions. Not investment advice.

Short interest

Total shares sold short as of each twice-monthly FINRA settlement. Rising short interest means more investors are positioned against the stock; days to cover estimates how many trading days of average volume that position represents.

Shares short
4.1M
settled 2026-08-14
Change vs prior
-8.0%
vs previous settlement
Days to cover
4.77
at avg daily volume
Avg daily volume
866.8K
FINRA reported
SettlementShares shortChangeDays to cover
2026-08-144.1M-8.0%4.77
2026-07-314.5M-12.1%5.05
2026-07-155.1M+10.9%6.78
2026-06-304.6M-0.7%5.70
2026-06-154.6M-21.8%5.19
2026-05-295.9M-10.2%8.62
2026-05-156.6M-4.1%8.21
2026-04-306.9M-5.3%6.40

Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data, which is included at no additional charge for your own personal or professional use; republishing or redistributing it is not permitted. Settlement dates are shown; FINRA publishes each settlement about nine business days later, so the latest figure can be two to four weeks old. Not presented as a percentage of float. No FINRA endorsement of this product is implied. Not investment advice.

Income statement (as reported)

 FY2025FY2024FY2023FY2022FY2021
Revenue$868.5M$714.7M$582.0M$437.9M$305.4M
Gross profit$670.1M$557.9M$460.8M$354.4M$249.9M
Operating income$208.5M$190.8M$192.0M$120.2M$87.5M
Net income$158.7M$145.5M$128.9M$181.5M$34.6M
Diluted EPS$2.71$2.51$2.13$2.97$0.58

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Balance sheet (as reported)

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Cash flow (as reported)

 FY2025FY2024FY2023FY2022FY2021
Operating cash flow$348.2M$219.8M$219.4M$144.5M$98.6M
Capital expenditure$310,000$1.2M$312,000$172,000$298,000
Free cash flow$347.9M$218.7M$219.1M$144.3M$98.3M

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Quarterly trend (as reported)

QuarterRevenueRevenue YoYNet incomeDiluted EPS
Q2 FY2026$261.3M30.3%$75.4M$1.28
Q1 FY2026$215.4M16.6%$32.5M$0.55
Q4 FY2025$243.8M21.1%$22.5M$0.39
Q3 FY2025$239.5M28.7%$50.9M$0.87
Q2 FY2025$200.5M16.0%$39.8M$0.68
Q1 FY2025$184.7M19.5%$45.6M$0.78
Q4 FY2024$201.3M19.5%$49.5M$0.85
Q3 FY2024$186.0M16.1%$46.1M$0.79

Latest 8 reported quarters, from company XBRL filings on SEC EDGAR.

Company facts

ExchangeNasdaq
SectorHealthcare
SIC industryPharmaceutical Preparations
Latest annual periodFY2025 (ended December 31, 2025)
Latest reported quarterQ2 FY2026 (ended June 30, 2026)
Oldest indexed filing2020
SEC CIK1802665

Selected SEC filings

10-K2026-02-24
View on EDGAR →
10-Q2026-08-04
View on EDGAR →
10-Q2026-05-07
View on EDGAR →
8-K2026-08-04
View on EDGAR →
8-K2026-07-16
View on EDGAR →
8-K2026-05-14
View on EDGAR →
8-K2026-05-07
View on EDGAR →

Largest pharmaceutical peers

All pharmaceutical stocksAll Healthcare companies →

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Data sourced from SEC EDGAR. Figures are as-reported and may be unaudited or restated; verify against the source filing before relying on them. Informational only. Not investment advice.