Amgen vs Exelixis (AMGN vs EXEL)
Side by side from their SEC filings: revenue, margins, growth, returns and valuation, plus short interest, insider activity and institutional ownership.
Amgen is the larger company by revenue ($36.8B vs $2.3B) and market value ($196.1B vs $14.0B). Exelixis has grown revenue faster over the last 4 fiscal years (+61.7% cumulative vs +41.5%). Exelixis runs the higher operating margin (37.6% vs 24.7%). Exelixis trades at the lower trailing P/E (18.6x vs 25.3x).
About Amgen
Amgen Inc discovers, develops, manufactures, and delivers medicines to treat serious diseases. The company offers products such as Repatha for cardiovascular risk, UPLIZNA for immunoglobulin G4-related disease and myasthenia gravis, and IMDELLTRA for small cell lung cancer. Amgen serves healthcare providers and patients worldwide, with a presence in about 100 countries and sales primarily through pharmaceutical wholesalers and direct-to-patient channels.
About Exelixis
Exelixis, Inc. is a biopharmaceutical company focused on developing and commercializing oncology medicines. Its main products include cabozantinib-based therapies marketed as CABOMETYX and COMETRIQ, which are approved to treat various forms of cancer such as renal cell carcinoma, hepatocellular carcinoma, thyroid cancer, and neuroendocrine tumors. The company serves patients and healthcare providers by advancing cancer treatment options through its internal research and strategic collaborations.
Head to head (AMGN FY2025 vs EXEL FY2025)
| Metric | AMGNFY2025 | EXELFY2025 |
|---|---|---|
| Revenue | $36.75B | $2.32B |
| Revenue growth (YoY) | 10.0% | 7.0% |
| Gross margin | 67.2% | — |
| Operating margin | 24.7% | 37.6% |
| Net margin | 21.0% | 33.7% |
| Net income | $7.71B | $782.6M |
| Diluted EPS | $14.23 | $2.78 |
| FCF margin | 22.0% | 37.7% |
| ROE | 89.1% | 36.2% |
| Debt / equity | 5.8× | — |
| Market cap | $196.12B | $14.02B |
| P/E (TTM) | 25.3× | 18.6× |
Fundamentals are from each company’s SEC filings (AMGN FY2025, EXEL FY2025). P/E and market cap are derived from recent market prices and update daily.
Five-year trend (as reported)
| AMGN by fiscal year | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
| Revenue | $25.98B | $26.32B | $28.19B | $33.42B | $36.75B |
| Net income | $5.89B | $6.55B | $6.72B | $4.09B | $7.71B |
| Operating margin | 29.4% | 36.3% | 28.0% | 21.7% | 24.7% |
| EXEL by fiscal year | FY2020 | FY2021 | FY2022 | FY2024 | FY2025 |
|---|---|---|---|---|---|
| Revenue | $1.43B | $1.61B | $1.83B | $2.17B | $2.32B |
| Net income | $231.1M | $182.3M | $207.8M | $521.3M | $782.6M |
| Operating margin | 20.0% | 12.5% | 9.3% | 27.9% | 37.6% |
Amgen and Exelixis use different fiscal calendars (AMGN's FY2025 ended 2025-12-31, EXEL's FY2025 ended 2026-01-02), so their fiscal years are shown separately rather than forced into one timeline.
Peer standing
Where each company ranks among the 71 biotech companies, on the same scale. Each figure is ranked only against peers that report it. Percentiles describe position in the distribution, not a rating.
| Metric | AMGN | EXEL |
|---|---|---|
| Operating margin | 24.7%70th percentile of 31 | 37.6%87th percentile of 31 |
| Net margin | 21.0%68th percentile of 32 | 33.7%90th percentile of 32 |
| FCF margin | 22.0%74th percentile of 28 | 37.7%85th percentile of 28 |
| Revenue growth (YoY) | +10.0%40th percentile of 64 | +7.0%38th percentile of 64 |
| ROE | 89.1%93rd percentile of 61 | 36.2%90th percentile of 61 |
| P/E (TTM) | 25.3×70th percentile of 21 | 18.6×55th percentile of 21 |
| Short interest (days to cover) | 3.93d39th percentile of 71 | 8.58d84th percentile of 71 |
Short interest
| FINRA settlement data | AMGN | EXEL |
|---|---|---|
| Shares sold short | 12.9M | 28.5M |
| Change vs prior settlement | +5.5% | -6.8% |
| Days to cover | 3.93 | 8.58 |
| As of settlement | 2026-06-30 | 2026-06-30 |
Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data; republishing or redistributing it is not permitted. Not presented as a percentage of float. No FINRA endorsement of this product is implied.
Insider activity (last 90 days)
| Form 4 open-market activity | AMGN | EXEL |
|---|---|---|
| Buys | 0 | 0 |
| Sells | 1 ($400,451) | 9 ($10.6M) |
Open-market purchases and sales reported on SEC Form 4 (grants, exercises and tax withholding excluded). For context, about 16% of covered companies saw any open-market insider buy in a 90-day window.
Held by the same investors
7 tracked 13F managers hold both Amgen and Exelixis as of their latest quarterly filings: AQR Capital Management, Bridgewater Associates, Citadel Advisors, D. E. Shaw, Gotham Asset Management, Millennium Management, Two Sigma Investments. See which superinvestors hold your own portfolio with the smart money checker.
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Data sourced from SEC EDGAR (public domain). Figures are as-reported and may be unaudited or restated; verify against the source filings before relying on them. Comparisons are descriptive (higher or lower on a reported figure), not a rating or a recommendation. Informational only. Not investment advice.