Amgen vs Biogen (AMGN vs BIIB)
Side by side from their SEC filings: revenue, margins, growth, returns and valuation, plus short interest, insider activity and institutional ownership.
Amgen is the larger company by revenue ($36.8B vs $9.9B) and market value ($236.9B vs $31.9B). Amgen has grown revenue faster over the last 4 fiscal years (+41.5% cumulative vs -9.9%). Amgen trades at the lower trailing P/E (27.2x vs 38.4x).
About Amgen
Amgen Inc discovers, develops, manufactures, and delivers medicines to treat serious diseases. The company offers products such as Repatha for cardiovascular risk, UPLIZNA for immunoglobulin G4-related disease and myasthenia gravis, and IMDELLTRA for small cell lung cancer. Amgen serves healthcare providers and patients worldwide, with a presence in about 100 countries and sales primarily through pharmaceutical wholesalers and direct-to-patient channels.
About Biogen
Biogen Inc. is a global biopharmaceutical company that discovers, develops, and delivers therapies for serious and complex diseases. It markets treatments for multiple sclerosis, spinal muscular atrophy, Friedreich's ataxia, amyotrophic lateral sclerosis, and collaborates on therapies for Alzheimer's disease and other conditions. The company also develops biosimilars and engages in research collaborations and acquisitions to advance its pipeline in neurology, immunology, and rare diseases.
Head to head (AMGN FY2025 vs BIIB FY2025)
| Metric | AMGNFY2025 | BIIBFY2025 |
|---|---|---|
| Revenue | $36.75B | $9.89B |
| Revenue growth (YoY) | 10.0% | 2.2% |
| Gross margin | 67.2% | 75.7% |
| Operating margin | 24.7% | — |
| Net margin | 21.0% | 13.1% |
| Net income | $7.71B | $1.29B |
| Diluted EPS | $14.23 | $8.79 |
| FCF margin | 22.0% | 20.7% |
| ROE | 89.1% | 7.1% |
| Long-term debt / equity | 5.78× | 0.34× |
| Market cap | $236.86B | $31.92B |
| P/E | 27.2× | 38.4× |
Fundamentals are from each company’s SEC filings (AMGN FY2025, BIIB FY2025). ROE is net income over fiscal-year-end equity; long-term debt / equity counts non-current term debt only. P/E and market cap are derived from stored market prices, last retrieved on a rolling basis and typically within the past week.
Five-year trend (as reported)
| Revenue | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
| AMGN | $25.98B | $26.32B | $28.19B | $33.42B | $36.75B |
| BIIB | $10.98B | $10.17B | $9.84B | $9.68B | $9.89B |
Peer standing
Where each company ranks among the 71 biotech companies, on the same scale. Each figure is ranked only against peers that report it. Percentiles describe position in the distribution, not a rating.
| Metric | AMGN | BIIB |
|---|---|---|
| Gross margin | 67.2%54th percentile of 14 | 75.7%77th percentile of 14 |
| Net margin | 21.0%68th percentile of 32 | 13.1%55th percentile of 32 |
| FCF margin | 22.0%74th percentile of 28 | 20.7%63rd percentile of 28 |
| Revenue growth (YoY) | +10.0%41st percentile of 64 | +2.2%33rd percentile of 64 |
| ROE | 89.1%95th percentile of 61 | 7.1%77th percentile of 61 |
| P/E | 27.2×68th percentile of 20 | 38.4×79th percentile of 20 |
| Long-term debt / equity | 5.78×95th percentile of 20 | 0.34×58th percentile of 20 |
| Short interest (days to cover) | 4.34d27th percentile of 71 | 6.13d41st percentile of 71 |
Short interest
| FINRA settlement data | AMGN | BIIB |
|---|---|---|
| Shares sold short | 12.0M | 5.2M |
| Change vs prior settlement | -9.3% | -4.8% |
| Days to cover | 4.34 | 6.13 |
| As of settlement | 2026-08-14 | 2026-08-14 |
Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data; republishing or redistributing it is not permitted. Not presented as a percentage of float. No FINRA endorsement of this product is implied.
Insider activity (last 90 days)
| Form 4 activity (codes P/S) | AMGN | BIIB |
|---|---|---|
| Buys | 0 | 0 |
| Sells | 6 ($4.1M) | 2 ($239,750) |
Non-derivative purchases (code P) and sales (code S) reported on SEC Form 4, which may be open-market or private (grants, exercises and tax withholding excluded). For context, about 15% of covered companies saw any reported insider purchase (code P) in a 90-day window.
Held by the same investors
5 tracked 13F managers hold both Amgen and Biogen as of their latest quarterly filings: AQR Capital Management, Citadel Advisors, D. E. Shaw, Gotham Asset Management, Two Sigma Investments. See which superinvestors hold your own portfolio with the smart money checker.
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Data sourced from SEC EDGAR. Figures are as-reported and may be unaudited or restated; verify against the source filings before relying on them. Comparisons are descriptive (higher or lower on a reported figure), not a rating or a recommendation. Informational only. Not investment advice.