Amgen vs Revolution Medicines (AMGN vs RVMD)
Side by side from their SEC filings: revenue, margins, growth, returns and valuation, plus short interest, insider activity and institutional ownership.
Amgen is the larger company by revenue ($36.8B vs $0) and market value ($236.9B vs $45.0B). Amgen has grown revenue faster over the last 4 fiscal years (+41.5% cumulative vs -100.0%).
About Amgen
Amgen Inc discovers, develops, manufactures, and delivers medicines to treat serious diseases. The company offers products such as Repatha for cardiovascular risk, UPLIZNA for immunoglobulin G4-related disease and myasthenia gravis, and IMDELLTRA for small cell lung cancer. Amgen serves healthcare providers and patients worldwide, with a presence in about 100 countries and sales primarily through pharmaceutical wholesalers and direct-to-patient channels.
About Revolution Medicines
Revolution Medicines, Inc. is a clinical-stage precision oncology company that develops targeted therapies for cancers driven by RAS mutations. The company focuses on small molecule inhibitors called RAS(ON) Inhibitors, designed to target active forms of RAS proteins in various cancers, including pancreatic ductal adenocarcinoma, non-small cell lung cancer, and colorectal cancer. Its pipeline includes multiple oral inhibitors tailored to specific RAS mutations, and it conducts clinical trials to evaluate these therapies in cancer patients.
Head to head (AMGN FY2025 vs RVMD FY2025)
| Metric | AMGNFY2025 | RVMDFY2025 |
|---|---|---|
| Revenue | $36.75B | $0 |
| Revenue growth (YoY) | 10.0% | — |
| Gross margin | 67.2% | — |
| Operating margin | 24.7% | — |
| Net margin | 21.0% | — |
| Net income | $7.71B | $-1.13B |
| Diluted EPS | $14.23 | $-5.95 |
| FCF margin | 22.0% | — |
| ROE | 89.1% | -69.3% |
| Long-term debt / equity | 5.78× | — |
| Market cap | $236.86B | $44.98B |
| P/E | 27.2× | — |
Fundamentals are from each company’s SEC filings (AMGN FY2025, RVMD FY2025). ROE is net income over fiscal-year-end equity; long-term debt / equity counts non-current term debt only. P/E and market cap are derived from stored market prices, last retrieved on a rolling basis and typically within the past week.
Five-year trend (as reported)
| Revenue | FY2021 | FY2022 | FY2023 | FY2024 | FY2025 |
|---|---|---|---|---|---|
| AMGN | $25.98B | $26.32B | $28.19B | $33.42B | $36.75B |
| RVMD | $29.4M | $35.4M | $11.6M | $0 | $0 |
Peer standing
Where each company ranks among the 71 biotech companies, on the same scale. Each figure is ranked only against peers that report it. Percentiles describe position in the distribution, not a rating.
| Metric | AMGN | RVMD |
|---|---|---|
| ROE | 89.1%95th percentile of 61 | -69.3%20th percentile of 61 |
| Short interest (days to cover) | 4.34d27th percentile of 71 | 6.36d43rd percentile of 71 |
Short interest
| FINRA settlement data | AMGN | RVMD |
|---|---|---|
| Shares sold short | 12.0M | 9.7M |
| Change vs prior settlement | -9.3% | -15.7% |
| Days to cover | 4.34 | 6.36 |
| As of settlement | 2026-08-14 | 2026-08-14 |
Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data; republishing or redistributing it is not permitted. Not presented as a percentage of float. No FINRA endorsement of this product is implied.
Insider activity (last 90 days)
| Form 4 activity (codes P/S) | AMGN | RVMD |
|---|---|---|
| Buys | 0 | 0 |
| Sells | 6 ($4.1M) | 51 ($53.9M) |
Non-derivative purchases (code P) and sales (code S) reported on SEC Form 4, which may be open-market or private (grants, exercises and tax withholding excluded). For context, about 15% of covered companies saw any reported insider purchase (code P) in a 90-day window.
Held by the same investors
6 tracked 13F managers hold both Amgen and Revolution Medicines as of their latest quarterly filings: AQR Capital Management, Citadel Advisors, D. E. Shaw, Gotham Asset Management, Millennium Management, Two Sigma Investments. See which superinvestors hold your own portfolio with the smart money checker.
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Data sourced from SEC EDGAR. Figures are as-reported and may be unaudited or restated; verify against the source filings before relying on them. Comparisons are descriptive (higher or lower on a reported figure), not a rating or a recommendation. Informational only. Not investment advice.