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Nasdaq · Healthcare

Twist Bioscience Corp (TWST)

As-reported financials and SEC filings for Twist Bioscience Corp. The latest annual period is FY2025. The latest reported quarter is Q3 FY2026. Financial statements come straight from the company’s EDGAR filings; valuation figures such as P/E and market cap use market data.

About Twist Bioscience Corp

Twist Bioscience Corp develops and manufactures synthetic DNA using a proprietary silicon-based platform that writes DNA on silicon chips. The company offers products and services including synthetic genes, oligonucleotide pools, next-generation sequencing tools, and biopharma services for antibody discovery and development. Twist serves customers in healthcare, chemicals and materials, food and agriculture, and academic research sectors worldwide.

Snapshot

Revenue
$376.6M
Revenue growth (YoY)
20.3%
Net income
$-77.7M
Diluted EPS
$-1.30
Gross margin
50.7%
Operating margin
-36.2%
Net margin
-20.6%
FCF margin
-20.1%
ROE
-16.4%
net income / fiscal-year-end equity
P/E
trailing when available, otherwise FY EPS
Market cap
$9.15B
Long-term debt / equity
non-current term debt only

Fundamentals are from SEC filings for FY2025, the latest annual period (ended September 30, 2025). P/E and market cap are derived from stored market prices, last retrieved on a rolling basis and typically within the past week.

What changed at Twist Bioscience

  • Revenue grew 20.3% to $377M in FY2025, slower than the 27.7% the year before.
  • Operating margin is -36.2% in FY2025, +79.2 pp against -115.4% in FY2021.
  • Most recent quarter Q3 FY2026: revenue $118M, up 23.2% from Q3 FY2025.
  • Free cash flow was negative $76M in FY2025.
  • Net loss narrowed to $78M in FY2025, from $209M in FY2024.

Computed from the as-reported figures in the statements below. A change we cannot state from filed figures is left out rather than estimated.

Peer comparison

Where Twist Bioscience’s fundamentals sit among the 71 biotech companies. Each figure is ranked only against peers that report it, from lowest (left) to highest (right).

Gross margin50.7%
15th percentile of 14
Operating margin-36.2%
17th percentile of 31
Net margin-20.6%
23rd percentile of 32
FCF margin-20.1%
30th percentile of 28
Revenue growth (YoY)+20.3%
52nd percentile of 64
ROE-16.4%
65th percentile of 61
Short interest7.90d
49th percentile of 71

Twist Bioscience’s gross margin of 50.7% ranks in the 15th percentile of the 14 biotech companies reporting it.

No reported insider purchases (code P) in the last 90 days; 44 insider sales totaling $47.4M. For context, about 15% of companies in the universe saw any reported insider purchase (code P) in the same window. Browse insider activity →

Percentiles describe where a figure sits among industry peers reporting it (100th = highest). They are position within a peer group, not a rating, and not investment advice. Short interest ranking uses days to cover from FINRA Consolidated Short Interest data; FINRA is the owner and source of that data, included at no additional charge.

Institutional ownership

Held by 4 of the superinvestors we track (plus 5 quant / multi-strat books), based on each investor’s most recent 13F; periods vary by investor (newest: Q2 2026).

Conviction investors
4
+5 quant / multi-strat
Initiated / added
6
2 new, 4 added
Reduced / exited
5
3 trimmed, 2 exited
Combined position
$745.4M
reported long value
InvestorAs ofPosition valueSharesChange
ARK Investment ManagementQ2 2026$468.1M4.5MReduced
D. E. ShawquantQ2 2026$122.0M1.2MAdded
Citadel AdvisorsquantQ2 2026$88.7M862.0KReduced
Millennium ManagementquantQ2 2026$35.7M347.1KReduced
AQR Capital ManagementquantQ2 2026$13.3M129.4KAdded
Two Sigma InvestmentsquantQ2 2026$9.7M94.6KAdded
Polen Capital ManagementQ2 2026$5.7M55.3KAdded
Bridgewater AssociatesQ2 2026$1.9M18.6KNew
Gotham Asset ManagementQ2 2026$326,0273.2KNew

No longer held by: Duquesne Family Office (as of Q2 2026), Point72 Asset Management (as of Q2 2026)

From quarterly Form 13F filings, which can be up to 45 days delayed. Long US-listed positions only: excludes short positions, options, cash, bonds, and non-US holdings, so this is not a manager’s complete portfolio. Counts are of the investors we track, not all institutions. Not investment advice.

Recent insider activity

Non-derivative buys and sells (codes P/S) reported by officers, directors and 10% owners on SEC Form 4.

Buys (90d)
0
code P
Bought (90d)
code P value
Sells (90d)
44
$47.4M
Reported activity
Net selling
by $ value, 90d
Trade dateInsiderTypeSharesPriceValue
2026-08-25
filed 2026-08-27
Leproust Emily M.Chief Executive OfficerSell12.6K$150.56$1.9M
2026-08-25
filed 2026-08-27
Leproust Emily M.Chief Executive OfficerSell12.2K$151.35$1.9M
2026-08-25
filed 2026-08-27
Leproust Emily M.Chief Executive OfficerSell9.2K$153.93$1.4M
2026-08-25
filed 2026-08-27
Leproust Emily M.Chief Executive OfficerSell6.4K$152.75$979K
2026-08-25
filed 2026-08-27
Leproust Emily M.Chief Executive OfficerSell1.1K$154.45$169K
2026-08-24
filed 2026-08-25
WERNER ROBERT F.Chief Accounting OfficerSell854$140.77$120K
2026-08-21
filed 2026-08-25
Leproust Emily M.Chief Executive OfficerSell6.6K$139.07$923K
2026-08-21
filed 2026-08-25
Finn Patrick JohnPresident and COOSell4.0K$139.07$563K
2026-08-21
filed 2026-08-25
Laponis AdamChief Financial OfficerSell2.0K$139.07$273K
2026-08-21
filed 2026-08-25
Cho DennisSee RemarksSell1.6K$139.07$222K
2026-08-21
filed 2026-08-25
Green PaulaSVP of Human ResourcesSell1.4K$139.07$189K
2026-08-21
filed 2026-08-25
WERNER ROBERT F.Chief Accounting OfficerSell669$139.07$93K

Reported non-derivative purchases and sales (codes P/S) — which may be open-market or private; excludes option exercises, grants, and shares withheld for taxes. Dates shown are the trade date; a Form 4 can be filed days to years later. A sale can be routine (e.g. a pre-set 10b5-1 plan), so read individual transactions in context. From SEC Form 4. Not investment advice.

Short interest

Total shares sold short as of each twice-monthly FINRA settlement. Rising short interest means more investors are positioned against the stock; days to cover estimates how many trading days of average volume that position represents.

Shares short
14.1M
settled 2026-08-14
Change vs prior
+0.2%
vs previous settlement
Days to cover
7.90
at avg daily volume
Avg daily volume
1.8M
FINRA reported
SettlementShares shortChangeDays to cover
2026-08-1414.1M+0.2%7.90
2026-07-3114.1M-0.3%11.12
2026-07-1514.1M+1.2%9.69
2026-06-3013.9M-21.0%5.51
2026-06-1517.7M+18.5%9.58
2026-05-2914.9M-10.1%8.99
2026-05-1516.6M+19.1%10.40
2026-04-3013.9M-4.2%10.46

Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data, which is included at no additional charge for your own personal or professional use; republishing or redistributing it is not permitted. Settlement dates are shown; FINRA publishes each settlement about nine business days later, so the latest figure can be two to four weeks old. Not presented as a percentage of float. No FINRA endorsement of this product is implied. Not investment advice.

Income statement (as reported)

 FY2025FY2024FY2023FY2022FY2021
Revenue$376.6M$313.0M$245.1M$203.6M$132.3M
Gross profit$191.0M$133.3M$89.7M$84.2M$51.7M
Operating income$-136.3M$-220.8M$-217.2M$-234.8M$-152.7M
Net income$-77.7M$-208.7M$-204.6M$-217.9M$-152.1M
Diluted EPS$-1.30$-3.60$-3.60$-4.04$-3.15

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Balance sheet (as reported)

 FY2025FY2024FY2023FY2022FY2021
Cash and equivalents$183.0M$226.3M$286.5M$378.7M$465.8M
Current assets$333.0M$346.8M$424.3M$596.5M$546.5M
Total assets$641.9M$614.3M$776.4M$961.4M$702.1M
Current liabilities$91.4M$71.0M$73.3M$90.7M$63.1M
Long-term debt
Total liabilities$168.9M$141.6M$153.0M$172.0M$121.3M
Total equity$473.0M$472.7M$623.4M$789.4M$580.8M

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Cash flow (as reported)

 FY2025FY2024FY2023FY2022FY2021
Operating cash flow$-47.6M$-64.1M$-142.5M$-124.4M$-112.2M
Capital expenditure$28.0M$5.1M$27.8M$101.9M$27.1M
Free cash flow$-75.6M$-69.2M$-170.3M$-226.2M$-139.3M

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (hover to see the figure as filed). Full details: where the numbers come from.

Quarterly trend (as reported)

QuarterRevenueRevenue YoYNet incomeDiluted EPS
Q3 FY2026$118.4M23.2%$-35.1M$-0.56
Q2 FY2026$110.7M19.3%$-44.0M$-0.71
Q1 FY2026$103.7M16.9%$-30.5M$-0.50
Q4 FY2025$99.0M16.9%$-27.1M$-0.45
Q3 FY2025$96.1M17.9%$20.4M$0.33
Q2 FY2025$92.8M23.2%$-39.3M$-0.66
Q1 FY2025$88.7M24.1%$-31.6M$-0.53
Q4 FY2024$84.7M26.5%$-34.7M$-0.59

Latest 8 reported quarters, from company XBRL filings on SEC EDGAR.

Company facts

ExchangeNasdaq
SectorHealthcare
SIC industryBiological Products, (No Diagnostic Substances)
Latest annual periodFY2025 (ended September 30, 2025)
Latest reported quarterQ3 FY2026 (ended June 30, 2026)
Oldest indexed filing2022
SEC CIK1581280

Selected SEC filings

10-Q2026-08-03
View on EDGAR →
8-K2026-08-19
View on EDGAR →
8-K2026-08-19
View on EDGAR →
8-K2026-08-05
View on EDGAR →
8-K2026-08-03
View on EDGAR →

Largest biotech peers

All biotech stocksAll Healthcare companies →

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Data sourced from SEC EDGAR. Figures are as-reported and may be unaudited or restated; verify against the source filing before relying on them. Informational only. Not investment advice.