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Nasdaq · Healthcare

Illumina, Inc. (ILMN)

As-reported financials and SEC filings for Illumina, Inc. The latest annual period is FY2025. The latest reported quarter is Q2 FY2026. Financial statements come straight from the company’s EDGAR filings; valuation figures such as P/E and market cap use market data.

About Illumina, Inc.

Illumina, Inc. develops and sells integrated systems for genetic analysis. Its main products include sequencing and microarray instruments and consumables used in research and clinical applications. The company serves customers in the life sciences, oncology, reproductive health, agriculture, and other fields.

Snapshot

Revenue
$4.34B
Revenue growth (YoY)
-0.7%
Net income
$850.0M
Diluted EPS
$5.45
Gross margin
66.1%
Operating margin
18.6%
Net margin
19.6%
FCF margin
21.4%
ROE
31.2%
net income / fiscal-year-end equity
P/E
50.6×
trailing when available, otherwise FY EPS
Market cap
$40.46B
Long-term debt / equity
—
non-current term debt only

Fundamentals are from SEC filings for FY2025, the latest annual period (ended December 28, 2025). P/E and market cap are derived from stored market prices, last retrieved on a rolling basis and typically within the past week.

What changed at Illumina

  • Revenue fell 0.7% to $4.3B in FY2025, after a 2.9% decline the year before.
  • Operating margin turned positive at 18.6% in FY2025, from a 2.7% operating loss in FY2021.
  • Most recent quarter Q2 FY2026: revenue $1.2B, up 9.4% from Q2 FY2025.
  • Free cash flow was $931M in FY2025, 21.4% of revenue.
  • Net income turned positive at $850M in FY2025, from a $1.2B loss in FY2024.

Computed from the as-reported figures in the statements below. A change we cannot state from filed figures is left out rather than estimated.

Peer comparison

Where Illumina’s fundamentals sit among the 570 Healthcare companies. Each figure is ranked only against peers that report it, from lowest (left) to highest (right).

Gross margin66.1%
64th percentile of 290
Operating margin18.6%
85th percentile of 410
Net margin19.6%
87th percentile of 429
FCF margin21.4%
88th percentile of 385
Revenue growth (YoY)-0.7%
26th percentile of 552
ROE31.2%
92nd percentile of 481
P/E50.6×
82nd percentile of 183
Short interest1.63d
15th percentile of 568

Illumina’s return on equity of 31.2% ranks in the 92nd percentile of the 481 Healthcare companies reporting it. Illumina’s FCF margin of 21.4% ranks in the 88th percentile of the 385 Healthcare companies reporting it. Illumina’s net margin of 19.6% ranks in the 87th percentile of the 429 Healthcare companies reporting it.

No reported insider purchases (code P) in the last 90 days; 69 insider sales totaling $436.5M. For context, about 15% of companies in the universe saw any reported insider purchase (code P) in the same window. Browse insider activity →

Percentiles describe where a figure sits among sector peers reporting it (100th = highest). They are position within a peer group, not a rating, and not investment advice. Short interest ranking uses days to cover from FINRA Consolidated Short Interest data; FINRA is the owner and source of that data, included at no additional charge.

Institutional ownership

Held by 4 of the superinvestors we track (plus 6 quant / multi-strat books), based on each investor’s most recent 13F; periods vary by investor (newest: Q2 2026).

Conviction investors
4
+6 quant / multi-strat
Initiated / added
2
0 new, 2 added
Reduced / exited
8
8 trimmed, 0 exited
Combined position
$1.55B
reported long value
InvestorAs ofPosition valueSharesChange
AQR Capital ManagementquantQ2 2026$623.2M3.5MReduced
Corvex ManagementQ2 2026$497.7M2.8MReduced
ARK Investment ManagementQ2 2026$183.7M1.0MReduced
Renaissance TechnologiesquantQ2 2026$145.3M826.6KReduced
Gotham Asset ManagementQ2 2026$62.6M356.2KAdded
Millennium ManagementquantQ2 2026$14.9M84.7KReduced
D. E. ShawquantQ2 2026$8.7M49.4KAdded
Point72 Asset ManagementquantQ2 2026$6.9M39.0KReduced
Two Sigma InvestmentsquantQ2 2026$4.1M23.2KReduced
Bridgewater AssociatesQ2 2026$2.2M12.6KReduced

From quarterly Form 13F filings, which can be up to 45 days delayed. Long US-listed positions only: excludes short positions, options, cash, bonds, and non-US holdings, so this is not a manager’s complete portfolio. Counts are of the investors we track, not all institutions. Not investment advice.

Recent insider activity

Non-derivative buys and sells (codes P/S) reported by officers, directors and 10% owners on SEC Form 4.

Buys (90d)
0
code P
Bought (90d)
—
code P value
Sells (90d)
69
$436.5M
Reported activity
Net selling
by $ value, 90d
Trade dateInsiderTypeSharesPriceValue
2026-09-04
Keith A. MeisterDirectorSell100.7K$218.39$22.0M
2026-09-04
Keith A. MeisterDirectorSell11.4K$219.18$2.5M
2026-09-04
Keith A. MeisterDirectorSell7.5K$217.28$1.6M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell14.2K$217.29$3.1M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell13.7K$219.41$3.0M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell13.3K$216.38$2.9M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell10.0K$221.55$2.2M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell9.7K$218.33$2.1M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell8.4K$215.20$1.8M
2026-09-03
filed 2026-09-04
Keith A. MeisterDirectorSell6.7K$220.17$1.5M
2026-09-02
filed 2026-09-04
Keith A. MeisterDirectorSell57.5K$213.20$12.3M
2026-09-02
filed 2026-09-04
Keith A. MeisterDirectorSell10.6K$213.73$2.3M

Reported non-derivative purchases and sales (codes P/S), which may be open-market or private. Excludes option exercises, grants, and shares withheld for taxes. Dates shown are the trade date; a Form 4 can be filed days to years later. A sale can be routine (e.g. a pre-set 10b5-1 plan), so read individual transactions in context. From SEC Form 4. Not investment advice.

Short interest

Total shares sold short as of each twice-monthly FINRA settlement. Rising short interest means more investors are positioned against the stock; days to cover estimates how many trading days of average volume that position represents.

Shares short
9.5M
settled 2026-09-30
Change vs prior
-10.5%
vs previous settlement
Days to cover
1.63
at avg daily volume
Avg daily volume
5.8M
FINRA reported
SettlementShares shortChangeDays to cover
2026-09-309.5M-10.5%1.63
2026-09-1510.6M+8.9%5.60
2026-08-319.7M+2.7%5.15
2026-08-149.5M+17.5%4.83
2026-07-318.1M-8.0%4.51
2026-07-158.8M+15.7%4.39
2026-06-307.6M-17.8%3.68
2026-06-159.2M+19.2%4.53

Source: FINRA Consolidated Short Interest. FINRA is the owner and source of the FINRA-supplied data, which is included at no additional charge for your own personal or professional use; republishing or redistributing it is not permitted. Settlement dates are shown; FINRA publishes each settlement about nine business days later, so the latest figure can be two to four weeks old. Not presented as a percentage of float. No FINRA endorsement of this product is implied. Not investment advice.

Income statement (as reported)

 FY2025FY2024FY2023FY2022FY2021
Revenue$4.34B$4.37B$4.50B$4.58B$4.53B
Gross profit
Operating income$807.0M$-833.0M$-1.07B$-4.18B$-123.0M
Net income$850.0M$-1.22B$-1.16B$-4.40B$762.0M
Diluted EPS$5.45$-7.69$-7.34$-28.00$5.04

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (tap or hover a figure to see how it was calculated or what was filed). Full details: where the numbers come from.

Balance sheet (as reported)

 FY2025FY2024FY2023FY2022FY2021
Cash and equivalents$1.42B$1.13B$1.05B$2.01B$1.23B
Current assets$3.29B$2.75B$2.61B$3.56B$2.71B
Total assets$6.64B$6.30B$10.11B$12.25B$15.22B
Current liabilities$1.58B$1.55B$1.57B$2.77B$1.09B
Long-term debt—————
Total liabilities
Total equity$2.72B$2.37B$5.75B$6.60B$10.74B

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (tap or hover a figure to see how it was calculated or what was filed). Full details: where the numbers come from.

Cash flow (as reported)

 FY2025FY2024FY2023FY2022FY2021
Operating cash flow$1.08B$837.0M$478.0M$392.0M$545.0M
Capital expenditure$148.0M$128.0M$195.0M$286.0M$208.0M
Free cash flow

Figures as reported to the SEC. Underlined values link to the filing they came from; dotted values are calculated by us from reported figures; “adj” means restated for a stock split (tap or hover a figure to see how it was calculated or what was filed). Full details: where the numbers come from.

Quarterly trend

QuarterRevenueRevenue YoYNet incomeDiluted EPS
Q2 FY2026$1.16B9.4%$207.0M$1.35
Q1 FY2026$1.09B4.8%$134.0M$0.87
Q4 FY2025——$334.0M—
Q3 FY2025$1.08B0.4%$150.0M$0.98
Q2 FY2025$1.06B-4.8%$235.0M$1.49
Q1 FY2025$1.04B-3.3%$131.0M$0.82
Q4 FY2024——$186.0M—
Q3 FY2024$1.08B-3.5%$705.0M$4.42

Latest 8 quarters, from company XBRL filings on SEC EDGAR. Revenue YoY is our calculation: each quarter against the same quarter a year earlier.

Company facts

ExchangeNasdaq
SectorHealthcare
SIC industryLaboratory Analytical Instruments
Latest annual periodFY2025 (ended December 28, 2025)
Latest reported quarterQ2 FY2026 (ended June 28, 2026)
Oldest indexed filing2019
SEC CIK1110803

Selected SEC filings

10-K2026-02-12
View on EDGAR →
10-K2025-02-12
View on EDGAR →
10-Q2026-07-31
View on EDGAR →
10-Q2026-05-04
View on EDGAR →
10-Q2025-10-31
View on EDGAR →
10-Q2025-08-01
View on EDGAR →
8-K2026-10-13
View on EDGAR →
8-K2026-08-17
View on EDGAR →

Largest Healthcare peers

All Healthcare companies →

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Data sourced from SEC EDGAR. Figures are as-reported and may be unaudited or restated; verify against the source filing before relying on them. Informational only. Not investment advice.